Chronic Carbon Tetrachloride Intoxication
نویسندگان
چکیده
منابع مشابه
Restoration of hepatic mitochondria during recovery from carbon tetrachloride intoxication.
-During CC14 intoxication in rats, a disruption of hepatic mitochondrial structure and function occurs, which is characterized by a loss of respiratory activity, loss of phosphorylation coupled to respiration, and mitochondrial swelling, attended by loss of cristae structure. Within 15-25 hr, after full development of the mitochondrial lesion, the function and structure of the mitochondria are ...
متن کاملChobert MN et al LIVER PRECURSOR CELLS INCREASE HEPATIC FIBROSIS INDUCED BY CHRONIC CARBON TETRACHLORIDE INTOXICATION IN RAT
Hepatic fibrosis, the major complication of virtually all types of chronic liver damage, usually begins in portal areas, and its severity has been correlated to liver progenitor cells (LPC) expansion from periportal areas, even if the primary targets of injury are intralobular hepatocytes. The aim of this study was to determine the potential fibrogenic role of LPC, using a new experimental mode...
متن کاملChronic restraint stress reduces carbon tetrachloride-induced liver fibrosis
Stress as a cofactor has been reported to affect the progression and severity of liver diseases. The present study investigated the effect of chronic restraint stress on carbon tetrachloride (CCl4)-induced liver fibrosis. A total of 30 male BALB/c mice were randomly divided into three groups: Oil-treated control group; CCl4-treated group; and CCl4 + restraint-treated group. CCl4 was administrat...
متن کاملThe role of Kupffer cells in carbon tetrachloride intoxication in mice.
Carbon tetrachloride (CCl(4))-induced acute hepatitis is assumed to involve two phases. The initial phase, initiated within 2 h after CCl(4) administration, involves the generation of reactive oxygen species. The second phase is assumed to start about 8 h subsequent to CCl(4) administration and involves the oxidant-induced activation of Kupffer cells, which release various pro-inflammatory medi...
متن کاملCarbon Tetrachloride in Helminthiasis
In the Journal of the American Mcdical Association of November 19th, 1921, there appeared a note by Maurice C. Hall on the use of Carbon tetrachloride for the removal of hookworms in animals. Dr. Hall is the senior zoologist, United States Bureau of Animal Industry, and he found this drug to be a powerful anthelmintic in dogs* and suggested its trial in human uncinariasis. Carbon tetrachloride ...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1944
ISSN: 1351-0711
DOI: 10.1136/oem.1.1.11